Renee Palmer (Jayne Heitmeyer) and J Street (Melinda Deines) take a freeze-dried Atavan mummy to Dr. Sam Foster, hoping the scientist will be able to suggest a way to kill the Atavus. They enter Foster's laboratory only to find the doctor dead. Suddenly, the Atavus who killed Foster emerges from the shadows, attacking Renee and Street. Renee shoots the alien, but its wound immediately heals. The alien flees from the lab, disappearing into the night.

Back at Augur's lair, Renee realizes that in order to learn how to kill the Atavus, they need the help of someone skilled in the art of death. She decides that Dr. Mataros (Margot Kidder), a pathologist and serial killer now on death row, is the perfect candidate. Against Street's protests, Renee goes to Rikers Federal Prison to meet Mataros. Posing as Mataros' attorney, she gains access to her cell and uses an ID portal to bring her back to the lair.

Mataros examines the Atavan mummy, but informs Renee that she would learn much more from examining a live hybrid. Refusing to provide the murderous doctor with a live subject, Renee and Street decide to put Mataros away for good. They take her to Sen-Dep Prison, a sensory-depravation facility where they hope even Ronald Sandoval (Von Flores), obsessed with finding the Atavans' weakness, won't be able to find her. Renee and Street are wrong, however. Tracing Mataros through electronic nanobots that were injected into the doctor while she was incarcerated, Sandoval catches up with them at Sen-Dep. Arriving in a helicopter, Sandoval and his men open fire from above the compound. In the midst of the chaos, Mataros renders Renee unconscious with chloroform and leads Street into the prison at gunpoint.

Renee recovers in time to flee from Sandoval and make her way back to the lair. Street, meanwhile, is freed by Mataros after the doctor finds an Atavus DNA scanner among Street's belongings. Street returns to the lair, where she and Renee are contacted by Mataros, who tells them she plans to use the scanner to find a hybrid of her own. Mataros finds a male hybrid that has just killed a woman in an alley behind a nightclub.

Knocking the hybrid out with an injection, Mataros returns to the lair with her new subject. Like an Atavus, however, the hybrid also has supreme healing powers and quickly recovers from both the sedative and the doctor's incisions. The alien attacks, but Renee is able to push him into an ID portal and beam his particles into limbo. Mataros dashes toward the portal and escapes. She makes her way to Sandoval and offers him her services in exchange for her freedom.

Mataros and Sandoval set up shop at the Whitecliff Hospital for the Criminally Insane. Mataros begins work on creating a new hybrid from one of Sandoval's henchmen. Renee breaks into the facility, finding Mataros extracting vital fluid from the hybrid. Knowing that she has to turn her discovery over to either Sandoval or Renee, Mataros suddenly injects herself with the fluid and collapses, apparently dead.

When Renee returns to the lair, she and Street receive a communication from Mataros, who informs them that she has decided to dedicate her life to learning more about the Atavus. Renee and Street are left to ponder whether they have a bizarre new ally in their battle against the Atavus, or have simply released a deadly new threat in the form of an alien empowered serial killer.

This episode synopsis was originally produced by The Official E:FC Website and remains the property of Tribune Entertainment.