Renee Palmer (Jayne Heitmeyer) and Captain Michaels (Dean McDermott) enjoy an intimate dinner at the lair. Suddenly, they receive an urgent video communication from one of Michaels' commandos, Sergeant Kirby (Jonathan Rannells), who is being attacked by a gang of hybrids. Renee and Michaels speed off to help him. After a brief firefight, they manage to free him from an Atavus joining chamber. The two rush Kirby, who has already been hybridized, to a vaccine processing plant for immediate treatment.

At the vaccine facility, Renee and Michaels are greeted by the head of the plant, Dr. Spangler (Andrea Roth). However, she shows more interest in Michaels than in the newly arrived patient. After sending Kirby for treatment in a private room, Spangler invites Michaels on a tour of the facility. Obviously jealous, Renee returns to the lair, where she receives a surprise visit from Raj'el (Helen Taylor). The Taelon informs Renee she is about to engage in the "final conflict," and advises her to adopt a more compassionate approach when dealing with the Atavus. Renee is appalled by the suggestion, especially given that she has lost her partner, Liam Kincaid, and former lover, Jeff Marlowe, to the deadly Atavus.

Raj'el departs, but leaves behind a gift box for Renee from archeologist and former boyfriend, Raleigh Sinclair. The box contains the jewels that served as eyes in the ancient Egyptian tomb of Askhenaton, containing maps to various Atavus hives. Renee gazes into the stones and sees old images from Howlyn's ship. Flooded with emotion, she immediately contacts Raj'el, demanding to know the location of Howlyn's ship, so that she can destroy it. Disappointed with Renee's continued aggression toward the Atavus, Raj'el employs a mind link, through which Renee recalls some of the bittersweet moments of the past few years.

Images such as William Boone's loss of his wife, Lili Marquette's union with a Jaridian, Liam's demise, and Renee's final moments with Boone begin to flood Renee's mind. Raj'el's message begins to hit home as Renee remembers that all beings, regardless of species, are "running from the same physical and emotional agonies." Renee then thinks back to when Raj'el shocked her with the news of Boone's death, the result of a hybrid uprising.

Back at the plant, Michaels runs into trouble when he notices that the vaccine being shipped out of the facility is a different color from that being administered to Kirby. When he confronts Spangler about the discrepancy, the doctor's armed guard shoots him. Badly wounded, Michaels manages to make his way to Kirby's room. Now a hybrid, Kirby betrays Michaels by forcing him at gunpoint back into the arms of Spangler and her guards, all of whom are hybrids. At the last moment, however, Kirby's loyalty resurfaces, and he opens fire on the guards. They return fire, killing him, as Michaels scurries for cover and contacts Renee for help.

Renee and a group of soldiers sweep into the plant. The troops overpower the guards, while Renee pursues Spangler. When Spangler opens fire, Renee shoots and kills her. Realizing that Michaels has succumbed to his wounds, Renee leaves, saddened that she must bid farewell to another loved one.

This episode synopsis was originally produced by The Official E:FC Website and remains the property of Tribune Entertainment.